The origin of this Jewish sect cannot definitely be traced. It was probably the outcome of the influence of Grecian customs and philosophy during the period of Greek domination. The first time they are met with is in connection with John the Baptist's ministry. They came out to him when on the banks of the Jordan, and he said to them, "O generation of vipers, who hath warned you to flee from the wrath to come?" ( Matthew 3:7 .) The next time they are spoken of they are represented as coming to our Lord tempting him. He calls them "hypocrites" and "a wicked and adulterous generation" ( Matthew 16:1-4 ; 22:23 ). The only reference to them in the Gospels of ( Mark 12:18-27 ) and ( Luke 20:27-38 ) is their attempting to ridicule the doctrine of the resurrection, which they denied, as they also denied the existence of angels. They are never mentioned in John's Gospel.
There were many Sadducees among the "elders" of the Sanhedrin. They seem, indeed, to have been as numerous as the Pharisees ( Acts 23:6 ). They showed their hatred of Jesus in taking part in his condemnation ( Matthew 16:21 ; Matthew 26:1-3 Matthew 26:59 ; Mark 8:31 ; 15:1 ; Luke 9:22 ; 22:66 ). They endeavoured to prohibit the apostles from preaching the resurrection of Christ ( Acts 2:24 Acts 2:31 Acts 2:32 ; Acts 4:1 Acts 4:2 ; Acts 5:17 Acts 5:24-28 ). They were the deists or sceptics of that age. They do not appear as a separate sect after the destruction of Jerusalem.