For out of the north there cometh up a nation against her
The Medes and Persians, which under Cyrus were one nation; and which not only lay north of Judea, where this prophecy came, but of Babylon, against which they were to come; and might lay more north to it, before the enlargement of their dominions; and besides, Cyrus came through Assyria to Babylon, which lay north of it; see ( Isaiah 41:25 ) . Thus, as Rome Pagan was sacked and taken by the Goths and Vandals, that came out of the north; so Rome Papal, and the antichristian states, will be destroyed by the Christian princes of the north, or those who have embraced what the Papists call the northern heresy; tidings out of the north shall trouble antichrist, ( Daniel 11:44 ) ; which shall make her land desolate, and none shall dwell therein;
that is, in process of time; for this desolation was not made at once; it was begun by Cyrus, made greater by Darius, and completed by Seleucus Nicator; they shall remove, they shall depart, both man and beast;
or, "from man to beast" F4; such as were not slain should either flee away or be carried captive; so that in time none should remain, either of man or beast; see ( Isaiah 13:19-22 ) ; and for the accomplishment of it on mystical Babylon see ( Revelation 18:2 Revelation 18:21-23 ) .