Deuteronomy 16:4

4 Let no yeast be found in any house throughout your land for those seven days. And when you sacrifice the Passover lamb on the evening of the first day, do not let any of the meat remain until the next morning.

Deuteronomy 16:4 Meaning and Commentary

Deuteronomy 16:4

And there shall be no leavened bread seen with thee in all thy
coasts seven days
For before the passover they were to search diligently every room in the house, and every hole and crevice, that none might remain any where; see ( Exodus 12:15 Exodus 12:19 ) ( 13:7 ) ,

neither shall there be anything of the flesh, which thou sacrificedst
the first day at even, remain all night until the morning;
which may be understood both of the flesh of the passover lamb, as Aben Ezra, according to ( Exodus 12:10 ) and of the flesh of flocks and herds, or of the Chagigah; according to Jarchi this Scripture speaks of the Chagigah of the fourteenth, which was not to remain on the first day of the feast (the fifteenth) until the morning of the second day (the sixteenth).

Deuteronomy 16:4 In-Context

2 Your Passover sacrifice may be from either the flock or the herd, and it must be sacrificed to the LORD your God at the designated place of worship—the place he chooses for his name to be honored.
3 Eat it with bread made without yeast. For seven days the bread you eat must be made without yeast, as when you escaped from Egypt in such a hurry. Eat this bread—the bread of suffering—so that as long as you live you will remember the day you departed from Egypt.
4 Let no yeast be found in any house throughout your land for those seven days. And when you sacrifice the Passover lamb on the evening of the first day, do not let any of the meat remain until the next morning.
5 “You may not sacrifice the Passover in just any of the towns that the LORD your God is giving you.
6 You must offer it only at the designated place of worship—the place the LORD your God chooses for his name to be honored. Sacrifice it there in the evening as the sun goes down on the anniversary of your exodus from Egypt.
Holy Bible. New Living Translation copyright© 1996, 2004, 2007, 2013 by Tyndale House Foundation. Used by permission of Tyndale House Publishers Inc., Carol Stream, Illinois 60188. All rights reserved.