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Isaiah 41:12

Ver. 12 Thou shall seek them, and shalt not find them
They not existing, or being fled into holes and corners, to rocks and mountains, to hide themselves from the wrath of the Lamb, ( Revelation 6:15-17 ) : even them that contended with thee;
or, "the men of thy contention" {p}; who contended with them, not by words and arguments, but by severe persecutions, striving thereby to hinder the progress of the Gospel, and to root Christianity out of the world: they that war against thee shall be as nothing, and as a thing of
nought:
or, "the men of thy war" F17; that proclaimed and carried on war against the Christians, in order to destroy them utterly; yet they, and all their efforts, came to nothing, the Gospel prevailed, and Paganism was utterly abolished; which came to pass in Constantine's time, at the opening of the sixth seal, ( Revelation 6:12-14 ) which is a proper comment on this text.
FOOTNOTES:

F16 (Kytum yvna) "viros jurgii tui", Montanus.
F17 (Ktmxlm yvna) "viri belli tui", Vatablus; "pugnae tuae", Montanus.
Read Isaiah 41:12