The eyes of the Lord preserve knowledge
That is, the providence of God, whose eyes run to and fro throughout the whole earth; these preserve the knowledge of himself, even among the Heathens in some measure; for what may be known of God is manifest in them, and showed to them: more particularly his providence has preserved the Scriptures, the means of knowledge, which men would have destroyed; and preserves men of knowledge, as Aben Ezra interprets it, the ministers of the word, the stars he holds in his right hand; and he preserves spiritual and experimental knowledge in the hearts of his people, and causes it to increase; and continues his Gospel and a Gospel ministry in the world, till they all come to the unity of the faith, and the knowledge of the Son of God. Or his eyes observe, look unto with delight and pleasure, knowledge and men of knowledge, that know him, and do his will; and he overthroweth the words of the transgressor;
the perfidious, treacherous man; the false teacher, that corrupts the word of God, and handles it deceitfully: the doctrines of such he overthrows, and confutes, and brings to nothing, by his Spirit in his faithful ministers; and causes truth to prevail, and all iniquity to stop its mouth: particularly the words and doctrines of the great transgressor, the lawless and wicked one, the man of sin, antichrist; these have been exposed and overthrown already, and will be more and more so in God's due time.
The Brenton translation of the Septuagint is in the public domain.