For mine enemies speak against, me
 Or "say unto me" F25 what is expressed in the following verse, "God hath forsaken him"; and so these words are a reason of the above petitions: or "mine enemies speak to me"; or "of me" F26; not good, but evil, and so the Targum paraphrases it, 
``for mine enemies speak evil against me;''or concerning me. David had his enemies, and many, as Ahithophel, and others, who spake against him to the people, and thereby drew many with them into rebellion against him; and particularly Shimei spoke against him, and cursed him, calling him a bloody man, a man of Belial, ( 2 Samuel 16:7 ) ;
 and they that lay wait for my soul;
 or "life"; that laid snares for him; or lay in ambush, and sought for an opportunity to take away his life: or "they that keep my soul", or "life" F1; that were his bodyguards that were about his person for the preservation of him; and so the Targum seems to understand it; 
 take counsel together;
 lay schemes and form plots how to destroy him, as Ahithophel did, (  2 Samuel 16:20-17:4 ) .