Mark 3:33

And he answered them
The multitude that sat about him, and informed him of his mother and brethren being without, and desirous of speaking with him:

saying, who is my mother, or my brethren?
which is said not through ignorance or contempt, but either, as displeased with the interruption given him; or with a view to take an opportunity from hence of expressing his superior value to his spiritual relations; which looks with no favourable aspect on the superstitious notions, and veneration of the virgin Mary among the papists; (See Gill on Matthew 12:48).