2 Thessalonians 2:3

Let no man deceive you by any means
By any of the above means; by pretending to a revelation from the Spirit; or to have had it from the mouth of anyone of the apostles; or to have a letter as from them, declaring the day of Christ to be instant; or by any other means whatever; do not be imposed upon by them for the following reasons, for there were things to be done before the coming of Christ, which were not then done, and which required time: for that day shall not come,

except there come a falling away first;
either in a political sense, of the nations from the Roman empire, which was divided into the eastern and western empire; for which, way was made by translating the seat of empire from Rome to Byzantium, or Constantinople; the former of these empires was seized by Mahomet, and still possessed by the Turks; and the latter was overrun by the Goths, Huns, and Vandals, and torn to pieces; Italy particularly was ravaged by them, and Rome itself was sacked and taken: or rather in a religious sense, of the falling of men from the faith of the Gospel, from the purity of Gospel doctrines, discipline, worship, and ordinances; and this not of some Jews who professed faith in Christ, and departed from it, or of some Christians who went off to the Gnostics; but is to be understood of a more general defection in the times of the Papacy; when not only the eastern churches were perverted and corrupted by Mahomet, and drawn off to his religion, but the western churches were most sadly depraved by the man of sin, by bringing in errors of all sorts in doctrine, making innovations in every ordinance, and appointing new ones, and introducing both Judaism and Paganism into the churches; which general defection continued until the times of the reformation, and is what the apostle has respect to in ( 1 Timothy 4:1-3 ) where he manifestly points out some of the Popish tenets, as forbidding marriage to priests, and ordering abstinence from meats on certain days, and at certain times of the year: this was one thing that was to precede the coming of Christ, another follows, which should take place at the same time;

and that man of sin be revealed;
who was now hid, though secretly working; by whom is meant not only any particular person or individual; not the devil, for though he is the wicked one, a damned spirit, an opposer, an adversary of God and Christ, and his people, and who has affected deity, and sought to be worshipped, and even by Christ himself; yet the man of sin is here distinguished from Satan, ( 2 Timothy 2:9 ) nor is any particular emperor of Rome intended, as Caius Caligula, or Nero, for though these were monsters of iniquity, and set up themselves as gods, yet they sat not in the temple of God; nor is Simon Magus designed, who was a very wicked man, a sorcerer, and who gave out himself to be some great one, and was called the great power of God, before big profession of faith in Christ; and afterwards affirmed that he was God, the Father in Samaria, the Son in Judea, and the Spirit in the rest of the nations of the world; and, because of his signs and lying wonders, had a statue erected by the Roman emperor with this inscription, "to Simon the holy god"; but then this wicked man was now already revealed: nor is this to be understood of a certain Jew, that is to be begotten by the devil on a virgin of the tribe of Dan, and who is to reign three years and a half, and then to be destroyed by Christ, which is a fable of the Papists; but a succession of men is here meant, as a king is used sometimes for an order and succession of kings, ( Deuteronomy 17:18 ) and an high priest for that whole order, from Aaron's time to the dissolution of it, ( Hebrews 9:7 ) so here it intends the whole hierarchy of Rome, monks, friars, priests, bishops, archbishops, cardinals, and especially popes, who may well be called "the man of sin", because notoriously sinful; not only sinners, but sin itself, a sink of sin, monsters of iniquity, spiritual wickednesses in high places: it is not easy to reckon up their impieties, their adulteries, incest, sodomy, rapine, murder, avarice, simony, perjury, lying, necromancy, familiarity with the devil, idolatry, witchcraft, and what not? and not only have they been guilty of the most notorious crimes themselves, but have been the patrons and encouragers of others in sin; by dispensing with the laws of God and man, by making sins to be venial, by granting indulgences and pardon for the worst of crimes, by licensing brothel houses, and countenancing all manner of wickedness; and therefore it is no wonder to hear of the following epithet,

the son of perdition;
since these are not only the Apollyon, the king of the bottomless pit, the destroyer, the cause of the perdition of thousands of souls, for the souls of men are their wares; but because they are by the righteous judgment of God appointed and consigned to everlasting destruction; the devil, the beast, and the false prophet, will have their portion together in the lake that burns with fire, ( Revelation 20:10 ) the same character as here is given of Judas, the betrayer of Christ, ( John 17:12 ) .