John 10:28

And I give unto them eternal life
Christ gives eternal life to his sheep, or people now; he gives them a spiritual life, or a life of grace, which issues in eternal life; he gives them himself, who is the true God and eternal life, and whoever has him has life; he gives them the knowledge of himself, which is life eternal; and he gives them his righteousness, which is their justification of life, or what entitles them to eternal life; and he gives them the foretastes of it, in faith and hope, in the enjoyment of himself, and the discoveries of his love; he gives them the earnest and pledge of it, his own Spirit; and they have this life in him as their representative, and it is hid with him in God, and is safe and secure for them; and he will actually give it to them in their own persons, to be for ever enjoyed by them; and because of the certainty of it, he is said to do it now: this is a pure gift, it is of grace, and not of works; and it is in the gift of Christ as Mediator, who has power to give it to as many as the Father has given him:

and they shall never perish;
though they were lost in Adam, and in a perishing condition in themselves, during their state of unregeneracy; in which condition they see themselves to be, when convinced by the Spirit of God; and come as persons ready to perish to Christ, as a Saviour, resolving, that if they perish, they will perish at his feet: and though after conversion, they are subject to many falls and spiritual declensions, and lose their peace, joy, and comfort, and imagine their strength and hope are perished, or at least fear they shall one day perish through one sin, or snare, or temptation or another, yet they shall never perish in such sense as the wicked will; they will not be punished with everlasting destruction from the presence of the Lord, and the glory of his power:

neither shall any pluck them out of my hand;
Christ's sheep are in his hands, being put there by God the Father, both as an instance of his love to Christ, and them; and this was done from all eternity, even when they were chosen in him; so that they were in the hands of Christ, before they were in the loins of Adam; and were preserved in him, notwithstanding Adam's fall, and through the ruins of it. To be in the hands of Christ, is to be high in his esteem and favour; the saints are a crown of glory in the hand of the Lord, and a royal diadem in the hand of their God; they are a signet on his right hand that shall never be plucked off; they are engraven on the palms of his hands: to be in the hands of Christ, is to be in his possession, and at his dispose, as all the elect of God are; and to be under his guidance, care, and protection, as they be; they are fed according to the integrity of his heart, and guided by the skilfulness of his hands; they are always under his care and watchful eye, who protects them from all their enemies, and hides them in the hollow of his hand: hence, because they are so, they are called "the sheep of his hand", ( Psalms 95:7 ) . And none shall ever pluck them from thence; no man can do it, not any false teacher can remove them from Christ, by all the art and cunning he is master of; nor any violent persecutor, by all the force and power he can use; nor can any sin, or snare, or temptation, draw them out of Christ's hands; nor any adversity whatever separate them from him: they must be safe, and always abide there, who are in the hands of Christ; for his hands have laid the foundations of the heavens and the earth, they grasp the whole universe, and hold all things together; and who then can pluck any out of these hands? Moreover, Christ, as Mediator, has all power in heaven and earth; and even as man, he is the man of God's right hand, made strong for himself.