Revelation 14:12

12 This calls for patient endurance on the part of the people of God who keep his commands and remain faithful to Jesus.

Read Revelation 14:12 Using Other Translations

Here is the patience of the saints: here are they that keep the commandments of God, and the faith of Jesus.
Here is a call for the endurance of the saints, those who keep the commandments of God and their faith in Jesus.
This means that God’s holy people must endure persecution patiently, obeying his commands and maintaining their faith in Jesus.

What does Revelation 14:12 mean?

John Gill's Exposition of the Bible
Revelation 14:12

Here is the patience of the saints
That which has required their patience, and about which it has been exercised, what they have been patiently waiting for, namely, the destruction of antichrist; and now it will be come, and patience will have its perfect work; see ( Revelation 13:10 ) here are they that keep the commandments of God;
and not the inventions of men, and the traditions of antichrist, but the ordinances of the Gospel, as they were at first delivered, without any adulteration and corruption; and who kept them because they were enjoined by God, and from a principle of love to him, and with a view to his glory: these are distinguished from the worshippers of the beast, and were preserved throughout the apostasy; these are the witnesses who will now be risen, and the remnant of the woman's seed, with whom the dragon made war by the beast: and these are the hundred and forty and four thousand who are before described; these will be in a very glorious and comfortable church state; the word will be purely preached, and the ordinances truly administered, and the doctrines of the Gospel will be heartily embraced and professed: it follows, and the faith of Jesus;
meaning either the grace of faith, of which Jesus is the object, author, and finisher; and which these saints will have from him, and exercise upon him in a very strong and comfortable manner; and which, and the profession of it, they will hold fast to the end; or else the doctrine of faith, concerning the person, office, and grace of Jesus Christ, the faith once delivered to the saints, which they will have contended for, stood fast in, and now will hold in a pure conscience: these seem to be the words of John, declaring the faith, patience, and obedience of the saints of these times.

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