Romans 3:12

They are all gone out of the way
In ( Psalms 14:3 ) ; it is said, "they are all gone aside"; as persons in debt: man had a considerable stock of righteousness, holiness, knowledge but he has run through all, has contracted large and numerous debts, has been obliged to hide himself, has been used as a bankrupt, and turned out of house and home: Christ indeed has undertook to pay, and he has paid all the debts of his people; and has put them into a better state than ever Adam was in: in ( Psalms 53:3 ) , it is rendered, "everyone of them is gone back"; that is, from God; from his commands, and from their former state and condition: here the phrase is rendered by the apostle, "they are all gone out of the way": that is, out of the way of God and his precepts, out of the way of holiness and righteousness, of light and life; into their own ways, the ways of sin, Satan, and the world of darkness, and of death: so Aben Ezra explains it, "out of the right way"; Kimchi and Ben Melech paraphrase it, "out of the good way: and so"

they are together become unprofitable;
the word (wxlan) , in ( Psalms 14:3 ) and ( Psalms 53:3 ) ; is translated, "they are become filthy"; which R. Aben Ezra interprets by (wtxvn) , "they are corrupt"; and R. Solomon Jarchi by (lwqlql wkphn) , "they are turned to corruption"; the metaphor is taken from stinking flesh, which is tainted and corrupted, and so good for nothing, hence here rendered "unprofitable"; for so men being corrupted by sin, are of no use, service, and advantage to God, to men, or to themselves; but, on the contrary, nauseous to God, and to all that are good, and hurtful to themselves and others: for

there is none that does good, no, not one;
and therefore must be unprofitable. There is none that can do good in a spiritual manner, without the grace of God, strength from Christ, and the assistance of the Spirit; and there is not even a spiritual man, that can do good perfectly, and without sin.