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Isaiah's question, "Is there anyone around who knows God's Spirit, anyone who knows what he is doing?" has been answered: Christ knows, and we have Christ's Spirit.
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For: who has known the Lord's mind, that he may instruct Him? But we have the mind of Christ.
1 Corinthians 2:16 In-Context
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The person without the Spirit does not accept the things that come from the Spirit of God but considers them foolishness, and cannot understand them because they are discerned only through the Spirit.
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The person with the Spirit makes judgments about all things, but such a person is not subject to merely human judgments,
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for, “Who has known the mind of the Lord so as to instruct him?”But we have the mind of Christ.