Ye shall seek me
That is, the Messiah, who he was; meaning, that after his departure they should be in great distress, and be very much on the inquiry after, and solicitous for the coming of the Messiah, to be a Redeemer and Deliverer of them out of their troubles:
and shall not find [me];
no Messiah will appear, no Saviour will be sent, no Redeemer will come to relieve them; they shall inquire, and look for one in vain, as they did.
And where I am, [thither] ye cannot come;
intimating hereby, that not only their temporal estate and condition would be very distressed and miserable, but also their eternal estate; since they should not be able to come where he would be in his human nature, and where he now was as a divine person, namely, in heaven.