al'-yen-at (`abhar; apallotrioo, "to estrange from"):

In Old Testament, for the break between husband and wife caused by unfaithfulness to the marriage vow (Jeremiah 6:8; Ezekiel 23:17); also applied to the diversion of property (Ezekiel 48:14). In New Testament, spiritually, for the turning of the soul from God (Ephesians 2:12; Colossians 1:21). The Greek allotrios, which is the root of the verb, is the opposite of id-i-os, "one's own." The word implies a former state, whence the person or thing has departed, and that, generally, by deterioration.

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Bibliography Information
Orr, James, M.A., D.D. General Editor. "Entry for 'ALIENATE'". "International Standard Bible Encyclopedia". 1915.