And I will smite the inhabitants of this city
With one or other of his arrows after mentioned: or, "them that abide in this city" {o}; that do not go out of it, and surrender themselves to the king of Babylon; see ( Jeremiah 21:9 ) ; both man and beast;
the latter for the sin of the former; particularly such beasts as were fit for food are meant, whereby the famine would be increased, and so the greater destruction of men: they shall die of a great pestilence;
both man and beast; a disease which comes immediately from the hand of God; hence Hippocrates used to call it (to yeion) , "the divine disease": here it denotes a very uncommon one, which should sweep away large numbers; called great, both for quality, or the nature of it, and for the quantity of persons that died of it.
The Brenton translation of the Septuagint is in the public domain.