Whosoever shall seek to save his life
 By fleeing to some strong hold, or by continuing in the metropolis, and strongest city in the nation, Jerusalem: 
 shall lose it:
 there he will be in the greatest danger: 
 and whosoever shall lose his life;
 or expose it to danger, by fleeing to the mountains, or going to Pella, a small town beyond Jordan, of no strength, and where there might be thought no security; 
shall preserve it; he shall be safe; (See Gill on Matthew 16:25).