What does the Bible say about bitterness? Bitterness is defined as anger and disappointment at being treated unfairly. It is synonymous with resentment and envy. One of the most well-known stories of bitterness in the Bible is the archetypal tale of Cain and Abel. Cain becomes consumed by bitterness for his brother and God when he feels unjustly treated relative to his prosperous brother Abel. Cain damns God and kills his brother out of hatred and pity for himself. This classic story warns us of the sinful essence of bitterness and to conversely have humility while in despair. We must take ownership of our situations and relinquish what is out of our control to God. Discover the most notable scripture quotes about bitterness in the Bible in this collection of verses!